| PHYL 301 - Human Physiology (6 credits) |
A lecture course on body function with particular reference to mammalian and human physiology. |
Lectures: Monday, Wednesday, Friday 11:00 am-12:00 noon
Required Textbook: Human Physiology, Ed. L. Sherwood & R. Kell, 1st Canadian Edition, 2010, Nelson.
Course Coordinator: Dr. K Kwok, Room #3013, Copp Building, Tel. 822-6228
Schedule/Course Info |
TERM I
Introduction (Kwok)
Neurophysiology (Mason)
CNS (Mason)
Muscle (Mason)
Body Fluids/Blood (Kwok)
Cardiovascular (Courneya) |
TERM II
Pulmonary (Osborne)
Renal (Kwok)
 - Concentration & Dilution of Urine
- Renal Transport
Gastrointestinal (Accili)
Endocrinology (Johnson)
Endocrinology/Reproductive (Kindler)
|
| PHYL 303 - Human Physiology Laboratory: Honours (3 credits) |
Techniques and principles of human physiology. Restricted to Honours Physiology and Pharmacology students. |
Laboratory: Thursday 2:00-5:00 pm
Course Coordinator: Dr. Sally Osborne, Room #3602, Copp Bldg, sally.osborne@ubc.ca, Tel. 822-3421, Web
TAs: Frank Huynh, Arya Mehran
Detailed Schedule/Course Info |
TERM I
Introduction (Osborne)
Informatics (Clee, Tanentzapf)
Lab Visits & Reception (All Faculty)
Epithelial Active Transport(Kehl)
Muscle Resting Potentials (Mason)
Neuroanatomy (Moukhles)
Stretch/Hoffman Reflex (Kehl)
Conduction Velocity (Haas)
CNS Tutorial I (Baimbridge, Krebs, Mason)
CNS Tutorial II (Baimbridge, Krebs, Mason)
Hematology & Serology (McIntosh)
ECG (Courneya)
|
TERM II
Introduction to Surgical Techniques (Baimbridge)
Surgical Technique (Baimbridge)
Regulation of Blood Pressure (Baimbridge)
Cardiopulmonary Tutorial I (Osborne/Courneya)/TBA
Cardiopulmonary Tutorial II (Osborne/Courneya)/TBA
Spirometry (Osborne)
Pharmacology I (Horne)
Pharmacology II (Horne)
Exercise & the Cardiopulmonary Response (Osborne)
Regulation of Human Renal Function (Kwok)
Human Oral Glucose Tolerance Test (Kindler)
Integrative Physiology (Osborne) |
| PHYL 422 - Mammalian Cardiovascular & Respiratory Physiology (3 credits) |
The control and integration of cardiopulmonary
function in mammals. |
Lectures: Tuesday & Thursday 8:00-10:00 am, September - December (Copp Bldg seminar room)
Course Coordinators: Dr. Sally Osborne (sally.osborne@ubc.ca, web) |
TOPICS
Cardiac Cycle (Courneya)
Regulation of Cardiac Output (Courneya)
Ionic Basis of the Action Potential: Lecture 1 / Lecture 2 (Ahern)
Autonomic regulation of heart rate (Accili)
ECG and Arrhythmias (Accili)
Excitation-Contraction Coupling/Regulation of Cardiac Contraction: Lecture / Nature Article (Moore)
Smooth Muscle (Moore)
Heart Failure (Moore)
Mechanics of Breathing (Osborne)
Principles of Diffusion & Blood Gas Transport (Osborne)
Distribution of Alveolar Ventilation & Perfusion (Osborne)
Causes of Hypoxemia (Osborne)
Control of Breathing (Osborne)
Breathing & Exercise (Guenette)
Breathing & Sleep; Breathing & Diving (Osborne)
Breathing in High Altitude (Osborne)
Breathing High Oxygen & Liquid Breathing (Osborne) |
| PHYL 423 - Mammalian Renal & Gastrointestinal Physiology (3 credits) |
Control of mammalian renal and gastrointestinal systems. |
Lectures: Tuesday &Thursday 2:00-4:00 pm, September-December (Copp Bldg Seminar Rm #2002/4)
Course Coordinator: Dr. C McIntosh, Room 5.320, Life Sciences Centre
Background Reading: Medical Physiology. A Cellular and Molecular Approach, 2nd Edition, Boron, W.F. and Boulpaep, E.L. Saunders, 2009.
Renal Physiology, 4th Edition, Koeppen B.M. and Stanton B.A., Mosby, 2007. Additional selected readings may be provided by Instructors. |
TOPICS
Introduction/Kidney Functional Anatomy/Renal Circulation (Kwok)
Glomerular Filtration I (Kwok)
Glomerular Filtration II (Kwok)
Introduction to Transport & Its Disorders (Peterson)
Objectives and Assessment (Peterson)
Group Assignments (Peterson)
Proximal Nephron: Na CoTransport & Glycosuria (Peterson)
Distal Nephron: Diuretics & Disorders (Peterson)
Quantificaton of Urinary Excretion/Acid-Base Balance I (Kwok)
Acid-Base Balance II/Fluid Compartments I (Kwok)
Fluid Compartments II (Kwok)
Functions of the Urinary Bladder (Kwok) |
GI Tract Overview (McIntosh)
GI Endocrinology (McIntosh)
GI Innervation & Taste Perception (Kieffer)
GI Innervation & Motility (Kieffer)
Gastric Secretion I (McIntosh)
Gastric Secretion II (McIntosh)
Exocrine Pancreas (McIntosh)
Intestinal Secretion/Water & Electrolyte Absorption (Accili)
The Liver (Clee)
GI Digestion & Absorption (McIntosh)
Integrated Response to a Meal (McIntosh)
|
PHYL 424 - Mammalian Endocrinology
(3 credits) |
Hormonal control of homeostatic, metabolic and reproductive function. |
January - April
Lectures: Tuesday, Thursday 2:00-4:00 pm (LSC Rm #1416)
Course Coordinator: Dr. KG Baimbridge, Room #3003A, Copp Building, Tel: 822-2330, Email: baim@interchange.ubc.ca |
This course is intended for Honours students in Physiology or other life sciences.
This course is eligible for Credit/D/Fail grading. You must register in the course before you can select the Credit/D/Fail grading option. Registered students only will have access to a PHYL 424 web site on UBC Vista. This is used for the posting of lecture notes and other relevant course material. In addition to attending lectures, students will also participate in group-based mini-presentations of selected hormonal diseases.
Prerequisite: A cumulative average of 75% over at least 90 credits attempted in the first three years of a student's program and a minimum mark of 75% in PHYL 301 or its equivalent. Permission of the course director is also required.
Course Assessment is based on mid-term and final examinations with equal weightings. Examinations are based upon lecture material only. There are no recommended textbooks for the course. |
TOPICS
Introduction (Baimbridge)
Membrane Receptors (McIntosh)
Intracellular Signalling Pathways 1 (Johnson)
Intracellular Signalling Pathways 2 (Johnson)
Steroid Receptors (Johnson)
Peptide Hormone Processing (Verchere)
Pancreas 1: Regulation of Insulin & Glucagon (Bruin)
Pancreas 2: EnteroInsular Axis (Kieffer)
Pancreas 3: Diabetes (Kieffer)
Immunology and Endocrinology (Johnson)
Hypothalamus/Pituitary Overview (McIntosh)
Growth Hormone (McIntosh)
|
Opioid Peptides (McIntosh)
Regulation of Food Intake & Body Weight (McIntosh)
Fat and Adipokines 1 (Clee)
Fat and Adipokines 2 (Clee)
Thyroid (Baimbridge)
Calcium Homeostasis (Baimbridge)
Hormones in Body Fluid Homeostasis (Kwok)
Adrenal Gland 1 (Baimbridge)
Adrenal Gland 2 (Baimbridge)
Reproductive Endocrinology 1 (Kindler)
Reproductive Endocrinology 2 (Kindler)
Reproductive Endocrinology 3 (Kindler) |
| PHYL 426 - Physiological Basis of Central Nervous System Functions (3 credits) |
An integrated study of the structural and functional organization of the central nervous system with special emphasis on neurophysiological mechanisms. |
January - April
Lectures: Tuesday, Thursday 8:00 - 9:50 am (Seminar Room, Copp Bldg)
Course Coordinator: Dr. Steven Kehl, LSC Room #2304, Tel: 822-2185, Email: skehl@interchange.ubc.ca
Prerequisites: PHYL 301. Permission from the Department Head is also required. |
TOPICS
Introduction/Review of Introductory Electrophysiology (Kehl)
Theory & Practice of Voltage-Clamp (Kehl)
General Equation for Macroscopic Current (Kehl)
First Order Reversible Reactions & Channel Gating (Kehl)
Voltage Clamp of Squid Giant Axon (SGA) (Kehl)
TEA+ Block of Delayed Rectifier Current as Example of Inward Rectification (Kehl)
Biophysics, Molecular Biology & Pharmacology of NaV channels (Kehl)
Computer Simulations of Hodgkin-Huxley Model of Macroscopic Currents (Kehl)
Action Potential Generation in SGA (Kehl)
Molecular Basis for N- & C-type Inactivation of KV Channels (Kehl)
Biophysics, Molecular Biology & Function of Kir (inward rectifier) Channels (Kehl)
Primus Inter Pares: Ca2+ ions & CaV Channels (Kehl)
Electrophysiological Aspects of Synaptic Transmission (Kehl)
Calcium Signaling in the Nervous System (Baimbridge)
Long-Term Potentiation (LTP) (Baimbridge)
Neurogenetics (Allan)
Neuronal Specification & Differentiation I (Allan)
Neuronal Specification & Differentiation II (Allan)
Axon Guidance Mechanisms (Allan)
Synaptogenesis (Haas)
Activity-Dependent Circuit Formation (Haas)
Neurotransmitter Receptors – Structure & Function: Glutamate & GABA (Haas)
Neural Encoding: Dendritic Integration & Action Potential Formation (Haas)
Neural Encoding: Circuit Activity Underlying Higher Brain Functions (Haas) |
| PHYL 430 - Advanced Laboratory in Physiology (6 credits) |
A laboratory course giving training in the methods, techniques and use of instruments required for physiological investigation. |
Laboratories: Fridays 10:00 am - 4:00 pm
Course Coordinator: Dr. B Mason, Room #3606, Copp Building
TAs: Gary Yang, Christian Peters, Blair Gage
* This is a Laboratory Course for 4th Year Honours Physiology Students * |
TOPICS - Term I
Orientation/Surgical Techniques I (Mason, Baimbridge)
Vascular Effects of Noradrenaline I (Baimbridge)
Vascular Effects of Noradrenaline II (Baimbridge)
Renal Function (Kwok)
Bioinformatics I (Clee, Tanentzapf)
Bioinformatics II (Clee, Tanentzapf)
Measurement of Human Respiratory Function (Osborne)
Skeletal Muscle Contractility (Mason)
GI Immunohistochemistry (Kieffer)
pH Regulation of Lipid Signalling (Loewen)
ECG (Courneya)
Environmental Physiology (Mason) |
TOPICS - Term II
Insulin I: Glucose Regulation of Insulin Expression (Kieffer)
Insulin II: OGTT (Kieffer)
Insulin III: ELISA (Kieffer)
Insulin IV: Viral Transfection (Kieffer)
Live Cell Ca2+ Imaging (Johnson)
Compound Action Potential (Mason)
Neurons in Action (Mason)
Intracellular Recordings I (Mason)
Intracellular Recordings II (Mason)
Two-Electrode Voltage Clamp (Ahern)
Electrophysiology Research Presentations (Mason)
|
PHYL 448 - Directed Studies in Physiology
(3-6 credits) |
|
Course Director: Dr. Steven Kehl (skehl@interchange.ubc.ca)
Description & Application |
| PHYL 449 - Graduating Essay (6 credits) |
A two term research project with a Department faculty member, culminating in a written thesis and an oral presentation to faculty. |
| Contact: Dr. Tim Kieffer, Rm 5308 Life Sciences Center (tim.kieffer@ubc.ca) |
| |
| |
| |
|
